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The amido- and sulfonamide pyrimidine containing polymers exhibited the most potent antimicrobial activity. Relative to your reference Gentamicin, the polymer 54 exhibited comparable antibacterial exercise versus gram unfavorable germs. Analogues 52 and 57 exhibited outstanding antibacterial routines compared to the references applied. Thus, these polyamides are very likely to be promising broad spectrum antibacterial agents and deserve additional investigation within the molecular degree.
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The polyamides are conveniently soluble in polar aprotic solvents like NMP, DMAc, DMF and DMSO whilst insoluble in boiling alcoholic or halogenated solvents. The noticed solubility with the pyridine-containing polyamide when compared to that polyamides made up of phenylene moiety may very well be attributed to your dipole–dipole interaction of polymer–solvent process.
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